If you spawn dozens of infinitely complex creatures in the Space Stage, your frame rate will drop, regardless of how powerful your graphics card is. The 32-bit engine can only utilize a limited amount of system RAM.
Creatures with dozens of limbs or heavily clustered joints may deform wildly, stretch across the screen, or completely break when the game tries to animate them walking. Spore Mod Unlimited Complexity
If you place thousands of parts on a single model, Spore may run out of addressable memory (RAM) and crash to the desktop. Save your progress frequently. If you spawn dozens of infinitely complex creatures
: Always start your game through the ModAPI Launcher, or the mods won't "hook" into the game engine. Pro-Tips for Infinite Building The "Force Save" Necessity your frame rate will drop