By this point in the series, Conan (Shinichi Kudo) has already faced off against the Black Organization. He has taken in the former organization member, Shiho Miyano (now Haibara Ai). Episode 143 is famous for one major reason:
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Before this episode, Ran saw Haibara as just another of Conan’s weird friends. After this, Ran sees a frightened child. When Ran holds Haibara and tells her, "Nothing will hurt you," it is heartbreakingly ironic because Ran does not know that the person threatening Haibara is the same organization that erased Shinichi. By this point in the series, Conan (Shinichi