Right-click pes6.exe -> Properties -> Compatibility -> Run as Windows XP (Service Pack 3). Windows blocks the administrator write permissions.
This prevents the game from hanging when you Alt-Tab. pes 6 no cd dvdrom drive found verified
Follow the patch installer instructions. These tools almost always rewrite the base game directory. Right-click pes6
Ensure the ISO remains mounted, and launch the game. pes 6 no cd dvdrom drive found verified
Use a tool like ImgBurn on an older PC to turn your physical disc into an .iso file.