A gameconfig change alone often isn't enough to prevent crashes when using many mods. You download and install these from GTA5-Mods.com:
This plugin fixes crashes related to reaching the maximum number of archive files ( .rpf ) the game can read at once. If you install dozens of individual add-on car packs, this tool is mandatory. Drop the files straight into your main game root folder. Troubleshooting Common Errors Game Crashes on the Loading Screen gta 5 gameconfig 1.0.350.1 download
The stock file shipped by Rockstar Games is strictly optimized for the base game. When you install custom add-on vehicles, the game quickly exhausts these hardcoded limits, resulting in an immediate crash. A modified gameconfig raises or completely removes these constraints. Why Version 1.0.350.1 Matters A gameconfig change alone often isn't enough to