To make a Nuzlocke more fair and playable, you can apply and "Standardize EXP Curves" settings. This helps ensure that early-game trainers don't have fully evolved pseudo-legendaries and that wild Pokémon follow standard growth patterns. Some challenge runners also suggest forcing the in-game "Challenge Mode" to make the game even more difficult.
The Ultimate Guide to Pokémon Black 2 Randomizer ROMs: Fresh Adventures in Unova Introduction pokemon black 2 randomizer rom
(Remember: do not host or link to copyrighted ROM files.) To make a Nuzlocke more fair and playable,
Mimics a regular game but with entirely shuffled regional themes. pokemon black 2 randomizer rom