Do not run any setup files. Simply extract the ZIP. You should see two files:
If you struggle to find a stable Due model for Proteus, or if you want to explore other free ecosystems, consider these options. arduino due library for proteus free download
If you cannot locate a specific Arduino Due library, or if the third-party libraries are causing issues, an alternative method exists: manually configuring the AVR microcontroller that powers the Arduino Due. Do not run any setup files